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Symbol
Name
ID

Knl1
kinetochore scaffold 1
MGI:1923714

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Primary microcephaly

Ventriculomegaly

Pachygyria

Hypoplasia of the frontal lobes

Agenesis of corpus callosum

Cerebellar vermis hypoplasia

Gray matter heterotopia

Delayed speech and language development

Aggressive behavior

Impulsivity

Intellectual disability

Intellectual disability, severe

Hyperreflexia

Bimanual synkinesia

Global developmental delay

Seizure

Disease(s) Associated with KNL1

primary autosomal recessive microcephaly

primary autosomal recessive microcephaly 4

Mouse Phenotypes		premature neuronal precursor differentiation	microgliosis	thin cortical plate	absent corpus callosum	telencephalon hypoplasia	decreased neuronal precursor cell number	decreased neuron number
Availability	Mouse Genotype	premature neuronal precursor differentiation	microgliosis	thin cortical plate	absent corpus callosum	telencephalon hypoplasia	decreased neuronal precursor cell number	decreased neuron number
	Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Emx1^tm1(cre)Krj/Emx1⁺ (conditional)
	Knl1^{tm1c(EUCOMM)Hmgu}/Knl1^{tm1c(EUCOMM)Hmgu} Tg(GFAP-cre)25Mes/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23